Pericytes for Therapeutic Approaches to Ischemic Stroke
نویسندگان
چکیده
منابع مشابه
Current AQP research: therapeutic approaches to ischemic and hemorrhagic stroke
The role of aquaporins (AQPs) in the formation of cerebral edema after stroke: Stroke can be classified into either ischemic or hemorrhagic based on their etiological mechanism. Cerebral edema development often accompanies both ischemic infarct and intracerebral hemorrhage (ICH). Cerebral edema is differentiated according to their underlying mechanism and time course: cytotoxic and vasogenic. C...
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Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. Consequently, the application of tPA has been strictly limited. Recent studies have indicated that matrix metalloproteinases (MMPs), especially MMP-9, play a critical role in blood brain barrier (BBB) disruption in the ischemic brain, leading to br...
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BACKGROUND Every year, strokes take millions of lives and leave millions of individuals living with permanent disabilities. Recently more researchers embrace the concept of the neurovascular unit (NVU), which encompasses neurons, endothelial cells (ECs), pericytes, astrocyte, microglia, and the extracellular matrix. It has been well-documented that NVU emerged as a new paradigm for the explorat...
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Intravenous recombinant tissue plasminogen activator remains the only US FDA-approved treatment for acute ischemic stroke. However, the very limited time window for its administration restricts its usefulness. Furthermore, it is becoming increasingly clear that, given the numerous pathways via which cerebral ischemia causes cell death, the capacity to inhibit multiple mechanisms simultaneously ...
متن کاملProgress in AQP Research and New Developments in Therapeutic Approaches to Ischemic and Hemorrhagic Stroke
Cerebral edema often manifests after the development of cerebrovascular disease, particularly in the case of stroke, both ischemic and hemorrhagic. Without clinical intervention, the influx of water into brain tissues leads to increased intracranial pressure, cerebral herniation, and ultimately death. Strategies to manage the development of edema constitute a major unmet therapeutic need. Howev...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2021
ISSN: 1662-453X
DOI: 10.3389/fnins.2021.629297